Noggin carves its niche
نویسندگان
چکیده
منابع مشابه
Noggin Antagonizes BMP Signaling to Create a Niche for Adult Neurogenesis
Large numbers of new neurons are born continuously in the adult subventricular zone (SVZ). The molecular niche of SVZ stem cells is poorly understood. Here, we show that the bone morphogenetic protein (BMP) antagonist Noggin is expressed by ependymal cells adjacent to the SVZ. SVZ cells were found to express BMPs as well as their cognate receptors. BMPs potently inhibited neurogenesis both in v...
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ژورنال
عنوان ژورنال: Nature Medicine
سال: 2001
ISSN: 1078-8956,1546-170X
DOI: 10.1038/84597